Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo. (September 2012)

• Record Type: Journal Article
• Authors: Sensenig, Richard; Sapir, Yulia; MacDonald, Cristin; Cohen, Smadar; Polyak, Boris
• Is Part Of: Nanomedicine. Volume 7:Number 9(2012)
• Page Start: 1425
• Page End: 1442
• Publication Date: 2012-09
• Subjects: cell therapy -- drug delivery -- forced transport -- magnetic cell seeding -- magnetic cell stimulation -- magnetic targeting -- patterned cell assemblies -- superparamagnetic nanoparticles -- time-varied magnetic field -- tissue engineering; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.12.109
• Languages: English
• ISSNs: 1743-5889

Abstract

Magnetic-based systems utilizing superparamagnetic nanoparticles and a magnetic field gradient to exert a force on these particles have been used in a wide range of biomedical applications. This review is focused on drug targeting applications that require penetration of a cellular barrier as well as strategies to improve the efficacy of targeting in these biomedical applications. Another focus of this review is regenerative applications utilizing tissue engineered scaffolds prepared with the aid of magnetic particles, the use of remote actuation for release of bioactive molecules and magneto–mechanical cell stimulation, cell seeding and cell patterning.