Comparative activity of a polyhexanide–betaine solution against biofilms produced by multidrug-resistant bacteria belonging to high-risk clones. Issue 1 (September 2019)

• Record Type: Journal Article
• Authors: Machuca, J.; Lopez-Rojas, R.; Fernandez-Cuenca, F.; Pascual, Á.
• Is Part Of: Journal of hospital infection. Volume 103:Issue 1(2019)
• Page Start: e92
• Page End: e96
• Publication Date: 2019-09
• Subjects: Biocides -- Biofilm -- Polyhexanide -- Betaine; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2019.04.008
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: The aim of this study was to investigate the effect of polyhexanide (polyhexamethylene biguanide)–betaine (PHMB-B) compared with 2% chlorhexidine against biofilms of high-risk and/or multidrug-resistant bacterial clones. The minimum inhibitory concentrations of both biocides were determined by microdilution. The effect of PHMB-B and chlorhexidine on biofilm was evaluated by spectrophotometry and cell viability assays. At commercial concentrations, PHMB-B reduced 24 h, 48 h and 1-week biofilms of all pathogens tested. PHMB-B was more active than 2% chlorhexidine against Gram-negative bacterial 24 h and 48 h biofilms and Gram-positive bacterial 7-day biofilms. In summary, the activity of PHMB-B was superior to that of 2% chlorhexidine in those biofilms.