Purinergic signalling and brain development. (November 2019)

• Record Type: Journal Article
• Authors: Rodrigues, Ricardo J.; Marques, Joana M.; Cunha, Rodrigo A.
• Is Part Of: Seminars in cell & developmental biology. Volume 95(2019)
• Page Start: 34
• Page End: 41
• Publication Date: 2019-11
• Subjects: Akt protein kinase B -- BDNF brain derived neurotrophic factor -- E embryonic day -- E-NPP ectonucleotide pyrophosphatase/phosphodiesterases -- NTPDase ectonucleoside triphosphate diphosphohydrolase -- GSK3 glycogen synthase kinase-3 -- IPC intermediate precursor cell -- MGE medial ganglionic eminence -- P1R P1 receptor -- P2R P2 receptor -- P2XR P2X receptor -- P2YR P2Y receptor -- PWMI periventricular white matter injury -- PFC prefrontal cortex -- PI3K phosphatidylinositol-4, 5-bisphosphate 3-kinase -- RGC radial glial cells -- SVZ subventricular zone -- TNAP tissue non-specific alkaline phosphatase -- vNUT vesicular nucleotide transporter -- VZ ventricular zon; ATP -- Adenosine -- P2 receptors -- P1 receptors -- Brain development -- Neuronal development; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2018.12.001
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: ATP and adenosine are released from cells as a function of their metabolic activity, being important cell-to-cell communication signals. Both purines are also released from neurons in an activity-dependent manner, with several established roles to fine tune brain function in adults, as best heralded by the effects of caffeine, an antagonist of adenosine receptors. Purines are also dynamically released from early neurogenesis and different purine receptors are dynamically expressed throughout development. Accordingly, emerging evidence supports multiple roles for purinergic signalling in the control of different processes of brain development, such as embryonic neurogenesis, migration of principal neurons and interneurons, guidance for neuronal connectivity, synaptogenesis and synaptic stability/elimination. Although major efforts are still required to unravel the time and space-related engagement of the different components of the purinergic system, the relevance of purines in brain development is heralded by their association with neurodevelopmental disorders, positing novel opportunities to understand and correct brain wiring.