Sustained release of levofloxacin from thermosensitive chitosan‐based hydrogel for the treatment of postoperative endophthalmitis. Issue 1 (21st March 2019)

• Record Type: Journal Article
• Authors: Cheng, Yung‐Hsin; Chang, Yu‐Fan; Ko, Yu‐Chieh; Liu, Catherine Jui‐ling
• Is Part Of: Journal of biomedical materials research. Volume 108:Issue 1(2020)
• Page Start: 8
• Page End: 13
• Publication Date: 2019-03-21
• Subjects: chitosan -- levofloxacin -- hydrogels -- sustained release; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.b.34359
• Languages: English
• ISSNs: 1552-4973

Abstract

Abstract: In the field of ophthalmology, postoperative endophthalmitis (POE) is a serious surgical complication, which may lead to poor visual outcome even after the infection has been controlled. In the study, we develop a sustained drug releasing system loaded with levofloxacin which is expected to be effective against common pathogens responsible for POE for at least 7 days after single application at the end of surgery. The results of study showed that the sol–gel transition temperature of the levofloxacin‐loaded chitosan‐gelatin‐based solution was ~34°C. The gelation time of the developed formulation was ~81 s at 34°C. The results showed that the osmolality of developed hydrogel was 304 mOsm/L. The in vitro drug release studies revealed that levofloxacin release from the developed hydrogel displayed a sustained‐release profile. The long‐term antibacterial property of the developed hydrogel has been demonstrated. The biocompatibility of the developed hydrogel was evaluated in vitro . These results suggest that the levofloxacin‐containing hydrogel could be applied to ocular surface at the end of ophthalmic surgery, without the risks of intracameral injection of antibiotics. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:8–13, 2020.