Dual‐energy CT iodine quantification for characterizing focal thyroid lesions. Issue 4 (18th December 2018)

• Record Type: Journal Article
• Authors: Lee, Do Hyung; Lee, Young Hen; Seo, Hyung Suk; Lee, Ki Yeol; Suh, Sang‐il; Ryoo, Inseon; You, Sung‐Hye; Kim, Byungjun; Yang, Kyung‐Sook
• Is Part Of: Head & neck. Volume 41:Issue 4(2019)
• Page Start: 1024
• Page End: 1031
• Publication Date: 2018-12-18
• Subjects: CT -- diagnosis -- differential -- dual‐energy -- iodine/analysis -- thyroid nodule; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25524
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: To determine the usefulness of dual‐energy CT (DECT) iodine quantification to classify the focal thyroid lesions. Methods: We retrospectively enrolled a total of 76 cytopathologically confirmed focal thyroid lesions (mean size: 1.9 cm). After drawing a region of interest on the DECT‐derived iodine maps, the obtained iodine concentration values of thyroid nodules (IC_N) and normalized IC_N were compared between 3 groups: papillary thyroid carcinoma (PTC), benign nodule, and cyst. Results: From all lesions, 46, 17, and 13 were assigned to the PTC, benign nodule, and cyst groups. IC_N was the highest in the benign nodule, lower in the PTC, and the lowest in the cyst (median [interquartile range]: 4.3 [3.13‐5.48], 3.15 [2.29‐4.01], 0.60 [0.33‐0.88], all P < .001). Similarly, the normalized IC_N values were all statistically different from each other ( P < .05).The multi‐class area under the curves using the optimal cutoff values were 0.931 for IC_N and 0.918, 0.920 for normalized IC, respectively. Conclusion: DECT iodine quantification could be helpful to classify the focal thyroid lesions.