MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementia. Issue 6 (15th March 2021)

• Record Type: Journal Article
• Authors: Manera, Ana L; Dadar, Mahsa; Van Swieten, John Cornelis; Borroni, Barbara; Sanchez-Valle, Raquel; Moreno, Fermin; Laforce Jr, Robert; Graff, Caroline; Synofzik, Matthis; Galimberti, Daniela; Rowe, James Benedict; Masellis, Mario; Tartaglia, Maria Carmela; Finger, Elizabeth; Vandenberghe, Rik; de Mendonca, Alexandre; Tagliavini, Fabrizio; Santana, Isabel; Butler, Christopher R; Gerhard, Alex; Danek, Adrian; Levin, Johannes; Otto, Markus; Frisoni, Giovanni; Ghidoni, Roberta; Sorbi, Sandro; Rohrer, Jonathan Daniel; Ducharme, Simon; Collins, D Louis
• Other Names: author non-byline.; Rosen Howard author non-byline.; Dickerson Bradford C. author non-byline.; Domoto-Reilly Kimoko author non-byline.; Knopman David author non-byline.; Boeve Bradley F. author non-byline.; Boxer Adam L. author non-byline.; Kornak John author non-byline.; Miller Bruce L. author non-byline.; Seeley William W. author non-byline.; Gorno-Tempini Maria-Luisa author non-byline.; McGinnis Scott author non-byline.; Mandelli Maria Luisa author non-byline.; author non-byline.; Afonso Sónia author non-byline.; Almeida Maria Rosario author non-byline.; Anderl-Straub Sarah author non-byline.; Andersson Christin author non-byline.; Antonell Anna author non-byline.; Archetti Silvana author non-byline.; Arighi Andrea author non-byline.; Balasa Mircea author non-byline.; Barandiaran Myriam author non-byline.; Bargalló Nuria author non-byline.; Bartha Robart author non-byline.; Bender Benjamin author non-byline.; Benussi Alberto author non-byline.; Benussi Luisa author non-byline.; Bessi Valentina author non-byline.; Binetti Giuliano author non-byline.; Black Sandra author non-byline.; Bocchetta Martina author non-byline.; Borrego-Ecija Sergi author non-byline.; Bras Jose author non-byline.; Bruffaerts Rose author non-byline.; Caroppo Paola author non-byline.; Cash David author non-byline.; Castelo-Branco Miguel author non-byline.; Convery Rhian author non-byline.; Cope Thomas author non-byline.; Cosseddu Maura author non-byline.; Arriba María de author non-byline.; Fede Giuseppe Di author non-byline.; Díaz Zigor author non-byline.; Duro Diana author non-byline.; Fenoglio Chiara author non-byline.; Ferrari Camilla author non-byline.; Ferreira Carlos author non-byline.; Ferreira Catarina B. author non-byline.; Flanagan Toby author non-byline.; Fox Nick author non-byline.; Freedman Morris author non-byline.; Fumagalli Giorgio author non-byline.; Gabilondo Alazne author non-byline.; Gasparotti Roberto author non-byline.; Gauthier Serge author non-byline.; Gazzina Stefano author non-byline.; Giaccone Giorgio author non-byline.; Gorostidi Ana author non-byline.; Greaves Caroline author non-byline.; Guerreiro Rita author non-byline.; Heller Carolin author non-byline.; Hoegen Tobias author non-byline.; Indakoetxea Begoña author non-byline.; Jelic Vesna author non-byline.; Jiskoot Lize author non-byline.; Karnath Hans-Otto author non-byline.; Keren Ron author non-byline.; Leitão Maria João author non-byline.; Lladó Albert author non-byline.; Lombardi Gemma author non-byline.; Loosli Sandra author non-byline.; Maruta Carolina author non-byline.; Mead Simon author non-byline.; Meeter Lieke author non-byline.; Miltenberger Gabriel author non-byline.; Minkelen Rick van author non-byline.; Mitchell Sara author non-byline.; Moore Katrina M author non-byline.; Nacmias Benedetta author non-byline.; Neason Mollie author non-byline.; Nicholas Jennifer author non-byline.; Öijerstedt Linn author non-byline.; Olives Jaume author non-byline.; Ourselin Sebastien author non-byline.; Padovani Alessandro author non-byline.; Panman Jessica author non-byline.; Papma Janne author non-byline.; Peakman Georgia author non-byline.; Piaceri Irene author non-byline.; Pievani Michela author non-byline.; Pijnenburg Yolande author non-byline.; Polito Cristina author non-byline.; Premi Enrico author non-byline.; Prioni Sara author non-byline.; Prix Catharina author non-byline.; Rademakers Rosa author non-byline.; Redaelli Veronica author non-byline.; Rittman Tim author non-byline.; Rogaeva Ekaterina author non-byline.; Rosa-Neto Pedro author non-byline.; Rossi Giacomina author non-byline.; Rossor Martin author non-byline.; Santiago Beatriz author non-byline.; Scarpini Elio author non-byline.; Schönecker Sonja author non-byline.; Semler Elisa author non-byline.; Shafei Rachelle author non-byline.; Shoesmith Christen author non-byline.; Tábuas-Pereira Miguel author non-byline.; Tainta Mikel author non-byline.; Taipa Ricardo author non-byline.; Tang-Wai David author non-byline.; Thomas David L author non-byline.; Thonberg Hakan author non-byline.; Timberlake Carolyn author non-byline.; Tiraboschi Pietro author non-byline.; Todd Emily author non-byline.; Vandamme Philip author non-byline.; Vandenbulcke Mathieu author non-byline.; Veldsman Michele author non-byline.; Verdelho Ana author non-byline.; Villanua Jorge author non-byline.; Warren Jason author non-byline.; Wilke Carlo author non-byline.; Woollacott Ione author non-byline.; Wlasich Elisabeth author non-byline.; Zetterberg Henrik author non-byline.; Zulaica Miren author non-byline.;
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 92:Issue 6(2021)
• Page Start: 608
• Page End: 616
• Publication Date: 2021-03-15
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2020-324106
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Introduction: Structural brain imaging is paramount for the diagnosis of behavioural variant of frontotemporal dementia (bvFTD), but it has low sensitivity leading to erroneous or late diagnosis. Methods: A total of 515 subjects from two different bvFTD cohorts (training and independent validation cohorts) were used to perform voxel-wise morphometric analysis to identify regions with significant differences between bvFTD and controls. A random forest classifier was used to individually predict bvFTD from deformation-based morphometry differences in isolation and together with semantic fluency. Tenfold cross validation was used to assess the performance of the classifier within the training cohort. A second held-out cohort of genetically confirmed bvFTD cases was used for additional validation. Results: Average 10-fold cross-validation accuracy was 89% (82% sensitivity, 93% specificity) using only MRI and 94% (89% sensitivity, 98% specificity) with the addition of semantic fluency. In the separate validation cohort of definite bvFTD, accuracy was 88% (81% sensitivity, 92% specificity) with MRI and 91% (79% sensitivity, 96% specificity) with added semantic fluency scores. Conclusion: Our results show that structural MRI and semantic fluency can accurately predict bvFTD at the individual subject level within a completely independent validation cohort coming from a different and independent database.