Pregnancy cohorts and biobanking in sub-Saharan Africa: a systematic review. Issue 11 (26th November 2020)

• Record Type: Journal Article
• Authors: Bone, Jeffrey N; Pickerill, Kelly; Woo Kinshella, Mai-Lei; Vidler, Marianne; Craik, Rachel; Poston, Lucilla; Stones, William; Sevene, Esperanca; Temmerman, Marleen; Koech Etyang, Angela; Roca, Anna; Russell, Donna; Tribe, Rachel M; von Dadelszen, Peter; Magee, Laura A
• Other Names: author non-byline.; D'Alessandro Umberto author non-byline.; Roca Anna author non-byline.; Jah Hawanatu author non-byline.; Oguchukwu Ofordile author non-byline.; Prentice Andrew author non-byline.; Martinez-Alvarez Melisa author non-byline.; Diallo Brahima author non-byline.; Sesey Adbul author non-byline.; Lette Kodou author non-byline.; Bah Alpha author non-byline.; Sanyang Chilel author non-byline.; Temmerman Marleen author non-byline.; Etyang Angela Koech author non-byline.; Musitia Peris author non-byline.; Amondi Mary author non-byline.; Chege David author non-byline.; Okiro Patricia author non-byline.; Omuse Geoffrey author non-byline.; Wanyonyi Sikolia author non-byline.; Sevene Esperança author non-byline.; Chin Paulo author non-byline.; Tchavana Corssino author non-byline.; Macuácua Salésio author non-byline.; Vála Anifa author non-byline.; Boene Helena author non-byline.; Quimice Lazaro author non-byline.; Maculuve Sonia author non-byline.; Macete Eusebio author non-byline.; Mandomando Inacio author non-byline.; Carillho Carla author non-byline.; Dadelszen Peter von author non-byline.; Magee Laura A author non-byline.; Flint-O'Kane Meriel author non-byline.; Craik Rachel author non-byline.; Strang Amber author non-byline.; Daniele Marina author non-byline.; Russell Donna author non-byline.; Makanga Tatenda author non-byline.; Makacha Liberty author non-byline.; Dube Yolisa author non-byline.; Nyapwere Newton author non-byline.; Poston Lucilla author non-byline.; Sandall Jane author non-byline.; Tribe Rachel author non-byline.; Shennan Andrew author non-byline.; Moore Sophie author non-byline.; Salisbury Tatiana author non-byline.; Barratt Ben author non-byline.; Beevers Sean author non-byline.; Bramham Kate author non-byline.; Papageorgiou Aris author non-byline.; Noble Alison author non-byline.; Blencowe Hannah author non-byline.; Filippi Veronique author non-byline.; Lawn Joy author non-byline.; Silver Matt author non-byline.; Chico Matthew author non-byline.; Cartwright Judith author non-byline.; Whitley Guy author non-byline.; Krishna Sanjeev author non-byline.; Vidler Marianne author non-byline.; Li Jing (Larry) author non-byline.; Bone Jeffrey author non-byline.; Woo Kinshella Mai-Lei (Maggie) author non-byline.; Payne Beth A author non-byline.; Tu Domena author non-byline.; Tumtaweetikul Warancha author non-byline.; Stones William author non-byline.; Volvert Marie-Laure author non-byline.; Chappell Lucy author non-byline.;
• Is Part Of: BMJ global health. Volume 5:Issue 11(2020)
• Publication Date: 2020-11-26
• Subjects: systematic review -- cohort study -- obstetrics -- maternal health; World health -- Periodicals; 362.105
• DOI: 10.1136/bmjgh-2020-003716
• Languages: English
• ISSNs: 2059-7908

Abstract

Abstract : Background: Technological advances and high throughput biological assays can facilitate discovery science in biobanks from population cohorts, including pregnant women. Biological pathways associated with health outcomes differ depending on geography, and high-income country data may not generalise to low-resource settings. We conducted a systematic review to identify prospective pregnancy cohorts in sub-Saharan Africa (SSA) that include biobanked samples with potential to enhance discovery science opportunity. Methods: Inclusion criteria were prospective data collection during pregnancy, with associated biobanking in SSA. Data sources included: scientific databases (with comprehensive search terms), grey literature, hand searching applicable reference lists and expert input. Results were screened in a three-stage process based on title, abstract and full text by two independent reviewers. The review is registered on PROSPERO (CRD42019147483). Results: Fourteen SSA studies met the inclusion criteria from database searches (n=8), reference list searches (n=2) and expert input (n=4). Three studies have ongoing data collection. The most represented countries were South Africa and Mozambique (Southern Africa) (n=3), Benin (Western Africa) (n=4) and Tanzania (Eastern Africa) (n=4); including an estimated 31 763 women. Samples commonly collected were blood, cord blood and placenta. Seven studies collected neonatal samples. Common clinical outcomes included maternal and perinatal mortality, malaria and preterm birth. Conclusions: Increasingly numerous pregnancy cohorts in SSA that include biobanking are generating a uniquely valuable resource for collaborative discovery science, and improved understanding of the high regional risks of maternal, fetal and neonatal morbidity and mortality. Future studies should align protocols and consider their added value and distinct contributions.