SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study. Issue 6 (5th February 2021)

• Record Type: Journal Article
• Authors: Pandanaboyana, Sanjay; Moir, John; Leeds, John S; Oppong, Kofi; Kanwar, Aditya; Marzouk, Ahmed; Belgaumkar, Ajay; Gupta, Ajay; Siriwardena, Ajith K; Haque, Ali Raza; Awan, Altaf; Balakrishnan, Anita; Rawashdeh, Arab; Ivanov, Bogdan; Parmar, Chetan; M Halloran, Christopher; Caruana, Clifford; Borg, Cynthia-Michelle; Gomez, Dhanny; Damaskos, Dimitrios; Karavias, Dimitrios; Finch, Guy; Ebied, Husam; K Pine, James; R A Skipworth, James; Milburn, James; Latif, Javed; Ratnam Apollos, Jeyakumar; El Kafsi, Jihène; Windsor, John A; Roberts, Keith; Wang, Kelvin; Ravi, Krish; V Coats, Maria; Hollyman, Marianne; Phillips, Mary; Okocha, Michael; SJ Wilson, Michael; A Ameer, Nadeem; Kumar, Nagappan; Shah, Nehal; Lapolla, Pierfrancesco; Magee, Connor; Al-Sarireh, Bilal; Lunevicius, Raimundas; Benhmida, Rami; Singhal, Rishi; Balachandra, Srinivasan; Demirli Atıcı, Semra; Jaunoo, Shameen; Dwerryhouse, Simon; Boyce, Tamsin; Charalampakis, Vasileios; Kanakala, Venkat; Abbas, Zaigham; Nayar, Manu;
• Other Names: author non-byline.; Altaf Abeer author non-byline.; Bahli Zahid author non-byline.; Ahmad Aman author non-byline.; Madhavan Anantha author non-byline.; Mingoli Andrea author non-byline.; White Angus author non-byline.; Cotton Arthur author non-byline.; Patel Ashiv author non-byline.; Apampa AyoBobola A author non-byline.; Famokunwa Bamidele author non-byline.; Rybinski Blazej author non-byline.; Cirillo Bruno author non-byline.; Ford Bryony author non-byline.; Jordan Caitlin author non-byline.; Jones Catrin author non-byline.; Varghese Chris author non-byline.; Konstantinou Charalampos author non-byline.; DermotStewart Charles Geoffrey author non-byline.; Wilson Colin author non-byline.; Marshall Daniel author non-byline.; Bourne David author non-byline.; Chandla Danny author non-byline.; Yeşilyurt Değercan author non-byline.; Manas Derek author non-byline.; Trivedi Dharmadev author non-byline.; Rutherford Duncan author non-byline.; Freed Ebru Sezen author non-byline.; Massie Eleanor author non-byline.; Ward Elizabeth author non-byline.; Murgitroyd Ellen author non-byline.; Britton Emily author non-byline.; Dickson Euan J author non-byline.; Tokidis Evripidis author non-byline.; Soliman Faris author non-byline.; Abbadessa Francesco author non-byline.; Singh Gautam author non-byline.; Gregory Gordon author non-byline.; Ugwu George author non-byline.; Brachini Gioia author non-byline.; Sen Gourab author non-byline.; Walmsley James author non-byline.; Khan Shabuddin author non-byline.; Said Hadil author non-byline.; Whewell Harriet author non-byline.; Spiers Harry VM author non-byline.; De'Ath Henry D author non-byline.; Bhatti Imran author non-byline.; Noaman Islam author non-byline.; Sert İsmail author non-byline.; Gossage James A author non-byline.; Martin Jack author non-byline.; Blackwell James author non-byline.; Williams James author non-byline.; Moore Jasmine Grace author non-byline.; Shepherd Jenna author non-byline.; Wheat Jennifer author non-byline.; Fenech Jeremy author non-byline.; French Jeremy author non-byline.; Scott John author non-byline.; Hammond John author non-byline.; James Anitha author non-byline.; Hartshorn Kai author non-byline.; Rowsell Kelsey author non-byline.; Philip Ken author non-byline.; Abdelgalel Khaled author non-byline.; McGivern Kieran author non-byline.; Brown Leo Richard author non-byline.; Howse Louise author non-byline.; Finch Louise M author non-byline.; Silva Louise author non-byline.; Patel Maitreyi author non-byline.; Kaur Mandeep author non-byline.; Quinn Marcus author non-byline.; Jama Marwa Ahmed author non-byline.; Lahiri Rajiv author non-byline.; Hopkins James author non-byline.; abousamra Mohamed author non-byline.; Issa Mohamed author non-byline.; Hammoda Mohammed author non-byline.; Qadeer Muhammad Ali author non-byline.; Zafar Muneeb author non-byline.; Bandlamudi Nanda author non-byline.; Chidumije Nnaemeka author non-byline.; Tiwari Navneet author non-byline.; Nwogwugwu Obi author non-byline.; Spence Olivia author non-byline.; Bassett Paul author non-byline.; Ghaneh Paula author non-byline.; Strong Paula author non-byline.; Szatmary Peter author non-byline.; Muhammad Qazi R author non-byline.; Nunes Quentin M author non-byline.; Atif Qurrat Al Ain author non-byline.; Sutton Robert author non-byline.; Young Robert author non-byline.; Taylor Roland author non-byline.; Tingle Sam author non-byline.; Saikia Samantha author non-byline.; Daniel Sudin author non-byline.; Jegatheeswaran Santhalingam author non-byline.; Halaseh Sattam author non-byline.; Noor Shehryar author non-byline.; McCluney Simon J author non-byline.; Allen Sophie author non-byline.; Goh Stephanie author non-byline.; Brown Steven author non-byline.; Cowie Stuart author non-byline.; Robinson Stuart author non-byline.; Kaya Tayfun author non-byline.; Tolley Thomas author non-byline.; Morrison-Jones Victoria author non-byline.;
• Is Part Of: Gut. Volume 70:Issue 6(2021)
• Page Start: 1061
• Page End: 1069
• Publication Date: 2021-02-05
• Subjects: acute pancreatitis -- pancreatitis -- COVID-19; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2020-323364
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Objective: There is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection. Design: A prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups. Results: 1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection. Conclusion: Patients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.