Reductive Amidation without an External Hydrogen Source Using Rhodium on Carbon Matrix as a Catalyst. Issue 1 (22nd November 2019)

• Record Type: Journal Article
• Authors: Tsygankov, Alexey A.; Makarova, Maria; Afanasyev, Oleg I.; Kashin, Alexey S.; Naumkin, Alexander V.; Loginov, Dmitry A.; Chusov, Denis
• Is Part Of: ChemCatChem. Volume 12:Issue 1(2020)
• Page Start: 112
• Page End: 117
• Publication Date: 2019-11-22
• Subjects: Amidation -- Homogeneous catalysis -- Heterogeneous catalysis -- Reduction -- Carbon monoxide; Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201901465
• Languages: English
• ISSNs: 1867-3880

Abstract

Abstract: An efficient method for preparation of secondary amides from primary amides and aldehydes using rhodium on carbon matrix as catalyst was developed. The method does not require any external hydrogen source and carbon monoxide is used as a reducing agent. The most active rhodium catalysts were characterized by BET, TEM and XPS techniques. Unexpectedly, it was found that heterogeneous rhodium on carbon matrix works as precatalyst for homogenous active species due to leaching of rhodium to the solution. Various secondary amides were synthesized and checked for antifungal activity. 4‐Methoxy‐N‐(4‐methoxybenzyl)benzamide demonstrated promising activity against Rhizoctonia Solani . Abstract : Leaching forever . Rhodium on carbon matrix was successfully applied as a catalyst for reductive amidation without an external hydrogen source. It was found that the reaction proceeds in homogeneous mode. The products were tested for antifungal activity.