The methylisothiazolinone epidemic goes along with changing patients' characteristics – After cosmetics, industrial applications are the focus. (17th November 2019)

• Record Type: Journal Article
• Authors: Schnuch, Axel; Schubert, Steffen; Lessmann, Holger; Geier, Johannes
• Other Names: Beiteke Ulrike investigator.; Dissemond Joachim investigator.; Buhl Timo investigator.; Schäkel Knut investigator.; Pföhler Claudia investigator.; Dietrich Cecilia investigator.; Worm Margitta investigator.; Bauer Andrea investigator.; Kreft Burkhard investigator.; Schliemann Sibylle investigator.; Brockow Knut investigator.; Becker Detlef investigator.; Forchhammer Stephan investigator.; Recke Andreas investigator.; Witte Jana investigator.; Pfützner Wolfgang investigator.; Coras‐Stepanek Brigitte investigator.; Skudlik Christoph investigator.; Wagner Nicola investigator.; Aberer Werner investigator.; Emmert Steffen investigator.; Baron Jens Malte investigator.; Siedlecki Katharina investigator.; Baur Vera investigator.; Schmieder Astrid investigator.; Weisshaar Elke investigator.; Grunwald‐Delitz Heidrun investigator.; Trautmann Axel investigator.; Hofmeier Kathrin Scherer investigator.; Szliska Christiane investigator.; Weiß Johannes investigator.; Effendy Isaak investigator.; Jünger Michael investigator.; Brehler Randolf investigator.; Rueff Franziska investigator.; Werfel Thomas investigator.; Dickel Heinrich investigator.; Rieker‐Schwienbacher Juliane investigator.; Vieluf Dieter investigator.; Stadler Rudolf investigator.; Simon Dagmar investigator.; Fartasch Manigé investigator.; Micaletto Sara investigator.; Treudler Regina investigator.; Nestoris Stefan investigator.; Mechtel Dirk investigator.; Schröder‐Kraft Claudia investigator.; Löffler Harald investigator.; Gina Michal investigator.; Koch André investigator.; Raap Ulrike investigator.; Grabbe Jürgen investigator.; Spring Philipp investigator.; Prager Welf investigator.; Wilfinger Daniel investigator.;
• Is Part Of: Contact dermatitis. Volume 82:Number 2(2020)
• Page Start: 87
• Page End: 93
• Publication Date: 2019-11-17
• Subjects: CAS no. 2682‐20‐4 -- clinical epidemiology -- contact sensitization -- face dermatitis -- methylisothiazolinone -- occupational dermatitis -- patch testing; Contact dermatitis -- Periodicals; 616.51
• DOI: 10.1111/cod.13414
• Languages: English
• ISSNs: 0105-1873

Abstract

Abstract: Background: Sensitization to methylisothiazolinone (MI) has seen an exceptional epidemic, mainly attributed to its use in cosmetics. Objectives: To trace the epidemic of MI allergy (2009–2018), and to analyze a possible change of patients' characteristics. Methods: Informationsverbund Dermatologischer Kliniken‐data of patients patch tested between 2009 and 2018 with MI (0.05% aq.) were analyzed concerning anamnestic items and sensitization frequencies. Results: Overall, 4.9% reacted positive to MI. Comparing sensitization to MI in three periods (2009, 2013/14, and 2017/18), there was an increase to 7% in 2013 and a decrease to 3.4% in 2018. The MOAHLFA Index (M=Men, O=Occupational Dermatitis, A=Atopic Dermatitis, L=Leg Dermatitis, F=Face Dermatitis, A= Age > 40) for the period 2013/14 is characterized by a lower proportion of occupational dermatitis and a higher proportion of face dermatitis. The period 2017/18 is characterized by increases of occupational dermatitis and hand dermatitis, and a decrease of face dermatitis. Painters, personal care workers, and hairdressers were particularly affected. Sensitization in hairdressers and personal care workers (mostly cosmeticians) decreased after the peak in 2013/14, whereas sensitization to MI in painters continued to increase. Conclusions: After an unprecedented epidemic of MI allergy, mainly caused by its use in cosmetics, the continuous use of MI in industrial applications, for example, paints, and subsequent sensitization remain a matter of concern. Highlights: After an epidemic of MI allergy mainly caused by its use in cosmetics, the continuous use of MI in industrial applications, for example, paints, and subsequent sensitization remain a matter of concern.