Association between neurodegenerative diseases and pneumonia: a retrospective population-based study. (3rd June 2019)

• Record Type: Journal Article
• Authors: Yeh, Jun-Jun; Lin, Cheng-Li; Hsu, Chung Y.; Shae, Zon-Yin; Kao, Chia-Hung
• Is Part Of: Current medical research and opinion. Volume 35:Number 6(2019)
• Page Start: 1033
• Page End: 1039
• Publication Date: 2019-06-03
• Subjects: Pneumonia -- neurodegenerative diseases -- statin -- population-based study; Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1080/03007995.2018.1552408
• Languages: English
• ISSNs: 0300-7995

Abstract

Abstract: Purpose: The association between pneumonia and neurodegenerative diseases (NDs) has never been reported in detail. We address this relationship with reference to the general population. Methods: Using Taiwan's National Health Insurance Research Database to identify a pneumonia cohort (including the typical and atypical), we established an ND cohort of 19, 062 patients and a non-ND cohort of 76, 227 people. In both cohorts, the risk of pneumonia was measured using multivariable Cox proportional hazards models. Results: The adjusted hazard ratio (aHR) (95% confidence interval [CI]) for the pneumonia cohort was 2.10 (1.96–2.24), regardless of age, sex, comorbidities or drug use in the ND cohort. The aHR (95% CI) for adults aged 20–49 years was 2.08 (1.58–2.75), men 2.20 (2.01–2.40). However, older subjects were at greatest risk of pneumonia, (3.41 [2.99–3.88]) if the 20–49 years age group is used as the reference. For the ND and non-ND cohorts, those with comorbidities (with the exception of hyperlipidemia) had higher risk; aHR (95% CI) 2.35 (2.30–2.52). The aHR (95% CI) for those without comorbidities is 3.28 (2.52–4.26). No significant difference was observed in incidence of pneumonia between those who were and were not using statin medications; the aHR (95% CI) was 1.03 (0.93–1.14). Conclusion: The ND cohort had a higher risk of pneumonia, regardless of age, sex, comorbidities or statin use. The risk of pneumonia was higher in elderly and male patients in the ND cohort.