Use of magnoflorine-phospholipid complex to permeate blood-brain barrier and treat depression in the CUMS animal model. (1st January 2019)

• Record Type: Journal Article
• Authors: Li, Bingjie; Han, Linmeng; Cao, Bingyan; Yang, Xiaoying; Zhu, Xuehui; Yang, Bing; Zhao, Haodong; Qiao, Wei
• Is Part Of: Drug delivery. Volume 26:Number 1(2019)
• Page Start: 566
• Page End: 574
• Publication Date: 2019-01-01
• Subjects: Magnoflorine-phospholipid complex -- physicochemical characterization -- in vivo blood-brain distribution -- pharmacological evaluation -- western blotting analysis; Drug delivery systems -- Periodicals; Drug targeting -- Periodicals; 615.05
• DOI: 10.1080/10717544.2019.1616236
• Languages: English
• ISSNs: 1071-7544

Abstract

Abstract: To improve the liposolubility and blood-brain barrier permeability of magnoflorine, a new formulation of magnoflorine-phospholipid complex was prepared, characterized, and pharmacologically evaluated in the chronic unpredictable mild stress animal model. In this paper, the magnoflorine-phospholipid complex was synthesized and its characterization was determined. The antidepressant-like and antioxidant activity of magnoflorine-phospholipid complex was investigated by behavioral tests and western blotting analysis. As a result, the magnoflorine-phospholipid complex displayed high encapsulation efficiency and significantly improved the oil-water participate coefficient. In vivo blood-brain distribution study, the magnoflorine-phospholipid complex extended the duration of magnoflorine in blood and help magnoflorine to permeate the blood-brain barrier into brain. In behavioral tests, the magnoflorine-phospholipid complex significantly decreased immobility time compared to model control group in both FST and TST. Furthermore, the magnoflorine-phospholipid complex increased the expression of antioxidative stress-related proteins by the western blotting analysis. These findings strongly suggest that the phospholipid complex could significantly improve liposolubility, drug properties of magnoflorine and help magnoflorine permeate blood-brain barrier and exert the antidepressant effect.