PH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin. (1st January 2019)

• Record Type: Journal Article
• Authors: Bu, Leran; Zhang, Hena; Xu, Kang; Du, Baixiang; Zhu, Caihong; Li, Yuling
• Is Part Of: Drug delivery. Volume 26:Number 1(2019)
• Page Start: 300
• Page End: 308
• Publication Date: 2019-01-01
• Subjects: Polyurethane -- micelle -- dual- responsive -- poly(2-ethyl-2-oxazoline) -- drug delivery; Drug delivery systems -- Periodicals; Drug targeting -- Periodicals; 615.05
• DOI: 10.1080/10717544.2019.1580323
• Languages: English
• ISSNs: 1071-7544

Abstract

Abstract: We describe a biodegradable amphiphilic polyurethane (PU) with disulfide bonds in the main chain [PEtOz- b -PU(SS)- b -PEtOz]. This multi-block PU was synthesized using poly (ε-caprolactone) diol (PCL-SS-PCL) and poly (2-ethyl-2-oxazoline) (PEtOz-OH) as soft segments, and bis (2-isocyanatoethyl) disulfide as the hard segment. Acid-sensitive PEtOz-OH was used as a hydrophilic segment for pH sensitivity. And reduction sensitivity was induced via disulfide bonds incorporated into the hydrophobic poly (ε-caprolactone) segment of the amphiphilic PUs. The system can self-assemble to form micelles responsive to pH and reducing conditions. The properties of the micelle were studied with dynamic light scattering and scanning electron microscopy. Doxorubicin (DOX) was chosen as a model drug. The in vitro release studies showed that PEtOz- b -PU(SS)- b -PEtOz micelle could degrade more rapidly and completely in a reductive and acidic environment [10 mM dl -Dithiothreitol, pH 5.0]. The methyl tetrazolium (MTT) assay and fluorescent microscopy confirmed the cytotoxicity of the DOX-loaded micelles. This work provides a promising dual-responsive drug carrier based on amphiphilic PU to achieve efficient drug delivery.