Long-term Ergotamine Derivative Therapy for Migraine Associated with Pachymeningitis and Sixth Cranial Nerve Palsy. (2nd November 2019)

• Record Type: Journal Article
• Authors: Tynan, Dominique; Ahmad, Kate; Thieben, Mark
• Is Part Of: Neuro-ophthalmology. Volume 43:Number 6(2019)
• Page Start: 417
• Page End: 420
• Publication Date: 2019-11-02
• Subjects: Paralysis -- palsy -- abducens nerve -- cranial nerve -- ergotamine -- migraine -- pachymeningitis; Neuroophthalmology -- Periodicals; 617.7
• DOI: 10.1080/01658107.2018.1526957
• Languages: English
• ISSNs: 0165-8107

Abstract

ABSTRACT: Chronic use of ergotamine derivatives has been well described in the literature to cause retroperitoneal, pleural, pericardial and valvular fibrosis. While acute migraine treatment advances have resulted in a reduction of ergotamine derivatives prescribing, they are still considered appropriate for some patients. We report a case of diffuse pachymeningitis with symptomatic right sixth cranial nerve palsy who had a history of long-term Cafergot© suppository use. To the best of our knowledge, this is the first case to temporally associate ergotamine derivatives with pachymeningitis.