Histological findings in patients with suspected mediastinal lymphoma relapse according to positive positron emission tomography scan during follow-up: a large retrospective analysis in 96 patients. Issue 9 (29th July 2019)

• Record Type: Journal Article
• Authors: Broccoli, Alessandro; Forti Parri, Sergio Nicola; Pellegrini, Cinzia; Casadei, Beatrice; Bonfanti, Barbara; Bertolaccini, Luca; Agostinelli, Claudio; Boaron, Maurizio; Fanti, Stefano; Nanni, Cristina; Argnani, Lisa; Zinzani, Pier Luigi
• Is Part Of: Leukemia & lymphoma. Volume 60:Issue 9(2019)
• Page Start: 2247
• Page End: 2254
• Publication Date: 2019-07-29
• Subjects: Follow-up -- mediastinal lymphoma -- positron emission tomography -- thoracoscopy -- mediastinotomy -- mediastinoscopy; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2019.1581931
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Residual masses in patients with mediastinal lymphoma may be positron emission tomography (PET) positive during follow-up also in cases of complete response. The aim of this retrospective study is to verify the reliability of mediastinal PET-positive findings in suggesting disease relapse or progression during follow-up by histological verification. From January 2002 to March 2016, 96 patients with mediastinal lymphoma underwent PET follow-up after front-line treatment. A surgical biopsy was performed to confirm the suspected relapse (for a total of 113 procedures). A lymphoma relapse was diagnosed in 66/102 successful procedures (64.7%). Diagnosis at relapse was concordant with the initial diagnosis in all but 3 cases. Standardized uptake value was significantly higher among patients with relapse than among those who remained in remission (10 versus 5, p < .05). PET scan helps individuate patients with a high suspect of lymphoma relapse and may guide the surgeon to the most suitable target.