Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke. (June 2021)

• Record Type: Journal Article
• Authors: Whitaker, Emmett E; Johnson, Abbie C; Miller, Justin E; Lindner, Devon P; Cipolla, Marilyn J
• Is Part Of: Mechanisms of ageing and development. Volume 196(2021)
• Publication Date: 2021-06
• Subjects: Preeclampsia -- Offspring -- Cerebral vasculature -- Middle cerebral artery -- Vein of galen; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2021.111491
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: Preeclampsia increases the risk for perinatal stroke in offspring. The reason for this increase in risk is not known. Preeclampsia induced systemic inflammation and oxidative stress. Preeclampsia altered structure and function of cerebral vessels in offspring. Alterations in vessel tone and response to vasoactive mediators occurred. Abstract: Preeclampsia, a hypertensive disorder of pregnancy, complicates up to 10 % of all pregnancies and increases the risk for perinatal stroke in offspring. The mechanism of this increase is unknown, but may involve vascular dysfunction. The goal of this study was to evaluate the effect of experimental preeclampsia (ePE) on cerebrovascular function in offspring to eludciate a possible mechanism for this association. Dams were fed a high cholesterol diet beginning on day 7 of gestation to induce experimental preeclampsia. Middle cerebral arteries (MCA) and the Vein of Galen (VoG) were isolated from pups from ePE dams and compared to pups from normal pregnant (NP) dams at postnatal days 16, 23, and 30 and studied pressurized in an arteriograph chamber. Markers of inflammation and oxidative stress were measured in serum. Our results suggest altered structure and function in both MCA and VoG of ePE pups. We also found evidence of systemic inflammation and oxidative stress in ePE pups. These findings provide a potential link between preeclampsia and the occurrence or severity of perinatal stroke.