An artificial pancreas based on simple control algorithms and physiological insight. Issue 1 (2019)

• Record Type: Journal Article
• Authors: Jørgensen, John Bagterp; Boiroux, Dimitri; Mahmoudi, Zeinab
• Is Part Of: IFAC-PapersOnLine. Volume 52:Issue 1(2019)
• Page Start: 1018
• Page End: 1023
• Publication Date: 2019
• Subjects: Control algorithm -- PID -- Feed-forward control -- Run-to-run control -- Diabetes -- Artificial pancreas; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2019.06.196
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.