Rituximab—A Drug with Many Facets and Cures: A Treatment for Acute Refractory Hypoxemic Respiratory Failure Secondary to Severe Granulomatosis with Polyangiitis. (14th February 2013)

• Record Type: Journal Article
• Authors: Powers, Braden; Uppalapati, Aditya; Gogineni, Sindhura; Akram Jamkhana, Zafar
• Other Names: Diez C. Academic Editor.; Doganay M. Academic Editor.; Lazzeri C. Academic Editor.; Pichler G. Academic Editor.; Reddy A. J. Academic Editor.; Waxman K. S. Academic Editor.
• Is Part Of: Case reports in critical care. Volume 2013(2013)
• Publication Date: 2013-02-14
• Subjects: Critical care medicine -- Periodicals; Emergency medicine -- Periodicals; Medical emergencies -- Periodicals; 616.02805
• DOI: 10.1155/2013/123134
• Languages: English
• ISSNs: 2090-6420

Abstract

Abstract : Granulomatosis with Polyangiitis (GPA) is a rare systemic anti neutrophil cytoplasmic antibody (ANCA-) associated granulomatous vasculitis of the small and medium sized blood vessels. Diffuse alveolar hemorrhage (DAH) is a rare life-threatening complication of GPA. In our patient, cyclophosphamide was held secondary to complications of acute kidney injury, hematuria, and concern for a possible hemorrhagic cystitis. However, during the workup for hematuria the patient acutely developed respiratory failure and was found to have DAH. The patient was initially supported with mechanical ventilation volume control mode, steroids, and plasma exchange. With no improvement of oxygenation, the mode of ventilation was changed to airway pressure release ventilation (APRV) and the patient was started on rituximab. The patient clinically improved over the next few days, was able to be extubated, and was transferred out of the intensive care unit.