Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients. (4th January 2017)

• Record Type: Journal Article
• Authors: Tandon, Vibha; Hiwale, Swati; Amle, Dnyanesh; Nagaria, Tripti; Patra, Pradeep Kumar
• Other Names: Fortuny Albert Academic Editor.
• Is Part Of: Journal of pregnancy. Volume 2017(2017)
• Publication Date: 2017-01-04
• Subjects: Pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; Pregnancy; Pregnancy Complications; Pregnancy; Pregnancy -- Complications; Electronic journals; Periodicals; Periodicals; 618.2
• DOI: 10.1155/2017/3179670
• Languages: English
• ISSNs: 2090-2727

Abstract

Abstract : Objective . The objective of the study was to assess the serum vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) and find association between serum VEGF levels and PIH. Methods . Thirty-five PIH subjects, 35 normal pregnant females, and 20 normal healthy females were included in the study. Detailed history, clinical examination, and relevant biochemical parameters were assessed; serum VEGF levels were estimated using Double-antibody enzyme-linked immunosorbent assay. Results . The study groups were found to be age matched (p = 0.38 ). VEGF level in the pregnancy-induced hypertensive group (median = 109.19 (3.38 ± 619 )) was significantly higher than the normal pregnant (median = 20.82 (1.7–619)) and control (median = 4.92 (1.13–13.07)) group and the difference between these three groups was significant (p < 0.0001 ). The 3 groups are found to be significantly different in terms of RBS (p = 0.01 ), urea (p < 0.0001 ), creatinine (p = 0.0005 ), AST (p = 0.0032 ), ALT (p = 0.0007 ), total protein (p = 0.0004 ), albumin (p < 0.0001 ), calcium (p = 0.001 ), and sodium (p = 0.02 ), while no statistically significant difference was found between total bilirubin (p = 0.167 ), direct bilirubin (p = 0.07 ), uric acid (p = 0.16 ), and potassium (p = 0.14 ). Conclusion . Significantly higher levels of serum VEGF were noted in PIH subjects compared to normal pregnant and control subjects.