Apoptosis and the Airway Epithelium. (13th December 2011)

• Record Type: Journal Article
• Authors: White, Steven R.
• Other Names: Knight Darryl A. Academic Editor.
• Is Part Of: Journal of allergy. Volume 2011(2011)
• Publication Date: 2011-12-13
• Subjects: Allergy -- Periodicals; Immunologic diseases -- Periodicals; Allergy and Immunology; Hypersensitivity; Immune System Diseases; Allergy; Immunologic diseases; Electronic journals; Periodical; Periodicals; 616.97
• DOI: 10.1155/2011/948406
• Languages: English
• ISSNs: 1687-9783

Abstract

Abstract : The airway epithelium functions as a barrier and front line of host defense in the lung. Apoptosis or programmed cell death can be elicited in the epithelium as a response to viral infection, exposure to allergen or to environmental toxins, or to drugs. While apoptosis can be induced via activation of death receptors on the cell surface or by disruption of mitochondrial polarity, epithelial cells compared to inflammatory cells are more resistant to apoptotic stimuli. This paper focuses on the response of airway epithelium to apoptosis in the normal state, apoptosis as a potential regulator of the number and types of epithelial cells in the airway, and the contribution of epithelial cell apoptosis in important airways diseases.