Ecofriendly and Facile One-Pot Multicomponent Synthesis of Thiopyrimidines under Microwave Irradiation. (8th April 2013)

• Record Type: Journal Article
• Authors: Sahoo, Biswa Mohan; Ravi Kumar, B. V. V.; Panda, Jnyanaranjan; Dinda, S. C.
• Other Names: Kauffmann Alexander Academic Editor.
• Is Part Of: Journal of nanoparticles. Volume 2013(2013)
• Publication Date: 2013-04-08
• Subjects: Nanoparticles -- Periodicals; 620.5
• DOI: 10.1155/2013/780786
• Languages: English
• ISSNs: 2314-484X

Abstract

Abstract : A rapid, improved, and ecofriendly synthesis of thiopyrimidines is carried out via one-pot multicomponent reaction of ethylcyanoacetate, substituted benzaldehydes, and thiourea in presence of ethanolic K2 CO3 using microwave irradiation heating method. Excellent yields, shorter reaction time, and easy workup are the major advantageous features of this green protocol. So the application of multicomponent reactions involves the combination of multiple starting materials with different functional groups leading to the highly efficient and environmentally friendly construction of multifunctional drug molecules. The structures of the newly synthesized products were assigned on the basis of IR and 1 HNMR spectral data.