Distinct Patterns of Host Adherence by Neisseria gonorrhoeae Isolated from Experimental Gonorrhea. (15th May 2021)

• Record Type: Journal Article
• Authors: He, Yingxia; Zhang, Song; Zhang, Yingmiao; Wu, Bicong; Xue, Ying; Ye, Chenglin; Li, Qiao; Olivia, Adhiambo Njiri; Tembo, John Mambwe; Chen, Hongxiang; Cai, Huahua; Chen, Tie
• Other Names: Detolla Louis Academic Editor.
• Is Part Of: Canadian journal of infectious diseases & medical microbiology =. Volume 2021(2021)
• Publication Date: 2021-05-15
• Subjects: Communicable diseases -- Periodicals; Infection -- Periodicals; Communicable diseases; Infection; Communicable Diseases; Communicable Disease Control; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; 616.9
• DOI: 10.1155/2021/7865405
• Languages: English
• ISSNs: 1712-9532

Abstract

Abstract : Neisseria gonorrhoeae ( N. gonorrhoeae, gonococci, or GC), the etiologic agent of gonorrhea, is a human-obligate bacterial pathogen. The GC surface contains pili that mediate the adherence to host cells. Studies have shown that GC pili, coded by pilin genes, undergo remarkable changes during human experimental gonorrhea, possibly generated by DNA phase variation during infection. The question that arises is whether the changes in pilins can alter the adherence capacity of N. gonorrhoeae to host cells. In this study, six variants initially isolated from male volunteers infected with one single clone of GC were examined for their adherence patterns with human Chang conjunctiva cells. In this study, we showed that the variants showed distinct adherence patterns to this cell line under light microscopy and scanning electron microscopy. Moreover, two reisolates showed higher adherence capacities than that of the input strain. The results provide an additional example as to how the pilus variation may play a role in the pathogenesis of N. gonorrhoeae .