The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation. (21st October 2012)

• Record Type: Journal Article
• Authors: Williams, Jesse W.; Tjota, Melissa Y.; Sperling, Anne I.
• Other Names: Hammad Hamida Academic Editor.
• Is Part Of: Journal of allergy. Volume 2012(2012)
• Publication Date: 2012-10-21
• Subjects: Allergy -- Periodicals; Immunologic diseases -- Periodicals; Allergy and Immunology; Hypersensitivity; Immune System Diseases; Allergy; Immunologic diseases; Electronic journals; Periodical; Periodicals; 616.97
• DOI: 10.1155/2012/236075
• Languages: English
• ISSNs: 1687-9783

Abstract

Abstract : In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (Fc γ R) signaling on antigen presenting cells (APC) for the induction of airway inflammation. These studies suggest a positive feedback loop between IgG produced by the adaptive B cell response and Fc γ R signaling on innate immune cells. Studies of IgG and Fc γ Rs in humans with asthma or allergic lung disease have been more controversial. Some reports have identified associations between allergen-specific IgG and severity of allergic responses, while other studies have found associations of IgG subclass IgG4 with allergic tolerance. In this paper, we review the literature to help define the nature of IgG and Fc γ R signaling on innate immune cells and how it contributes to the development of allergic immune responses.