Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors. (31st August 2010)

• Record Type: Journal Article
• Authors: Brassesco, María Sol; Xavier, Danilo Jordão; Camparoto, Marjori Leiva; Montaldi, Ana Paula; de Godoy, Paulo Roberto D'Auria Vieira; Scrideli, Carlos Alberto; Tone, Luiz Gonzaga; Sakamoto-Hojo, Elza Tiemi
• Other Names: Muller Hans Konrad Academic Editor.
• Is Part Of: Journal of biomedicine and biotechnology. Volume 2011(2011)
• Publication Date: 2010-08-31
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Medicine; Biology; Biotechnology; Médecine; Biologie; Biotechnologie; Biology; Biotechnology; Medicine; Biotechnology; Biomedicine; Electronic journals; Periodical; Periodicals; Electronic journals; 610
• DOI: 10.1155/2011/230481
• Languages: English
• ISSNs: 1110-7243

Abstract

Abstract : Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort.