Night shift work is associated with an increased risk of asthma. Issue 1 (16th November 2020)

• Record Type: Journal Article
• Authors: Maidstone, Robert J; Turner, James; Vetter, Celine; Dashti, Hassan S; Saxena, Richa; Scheer, Frank A J L; Shea, Steven A; Kyle, Simon D; Lawlor, Deborah A; Loudon, Andrew S I; Blaikley, John F; Rutter, Martin K; Ray, David W; Durrington, Hannah Jane
• Is Part Of: Thorax. Volume 76:Issue 1(2021)
• Page Start: 53
• Page End: 60
• Publication Date: 2020-11-16
• Subjects: asthma epidemiology -- asthma; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2020-215218
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Introduction: Shift work causes misalignment between internal circadian time and the external light/dark cycle and is associated with metabolic disorders and cancer. Approximately 20% of the working population in industrialised countries work permanent or rotating night shifts, exposing this large population to the risk of circadian misalignment-driven disease. Analysis of the impact of shift work on chronic inflammatory diseases is lacking. We investigated the association between shift work and asthma. Methods: We describe the cross-sectional relationship between shift work and prevalent asthma in >280000 UK Biobank participants, making adjustments for major confounding factors (smoking history, ethnicity, socioeconomic status, physical activity, body mass index). We also investigated chronotype. Results: Compared with day workers, 'permanent' night shift workers had a higher likelihood of moderate-severe asthma (OR 1.36 (95% CI 1.03 to 1.8)) and all asthma (OR 1.23 (95% CI 1.03 to 1.46)). Individuals doing any type of shift work had higher adjusted odds of wheeze/whistling in the chest. Shift workers who never or rarely worked on nights and people working permanent nights had a higher adjusted likelihood of having reduced lung function (FEV1 <80% predicted). We found an increase in the risk of moderate-severe asthma in morning chronotypes working irregular shifts, including nights (OR 1.55 (95% CI 1.06 to 2.27)). Conclusions: The public health implications of these findings are far-reaching due to the high prevalence and co-occurrence of both asthma and shift work. Future longitudinal follow-up studies are needed to determine if modifying shift work schedules to take into account chronotype might present a public health measure to reduce the risk of developing inflammatory diseases such as asthma.