Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI. Issue 2 (2nd November 2020)

• Record Type: Journal Article
• Authors: Myc, Lukasz; Qing, Kun; He, Mu; Tustison, Nicholas; Lin, Zixuan; Manichaikul, Ani W; Patrie, James; Cassani, Joanne; Nunoo-Asare, Roselove N; Huang, Yong; Obaida, Zaid; Tafti, Sina; Ropp, Alan M; Miller, Grady Wilson; Mata, Jaime; Altes, Talissa; Mugler, John; Shim, Y Michael
• Is Part Of: Thorax. Volume 76:Issue 2(2021)
• Page Start: 178
• Page End: 181
• Publication Date: 2020-11-02
• Subjects: COPD ÀÜ mechanisms -- imaging/CT MRI etc -- COPD pathology -- emphysema -- lung physiology -- respiratory measurement; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2020-214924
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow abnormality quantified by HXeMRI and per cent predicted forced expiratory volume in 1 s; HXeMRI gas transfer capacity to red blood cells and carbon monoxide diffusion capacity (%DLCO); and HXeMRI gas transfer capacity to interstitium and per cent emphysema quantified by multidetector chest CT. We further demonstrate the capability of HXeMRI to distinguish varying pathology underlying COPD in subjects with low %DLCO and minimal emphysema.