Biomarkers of Cervical Dysplasia and Carcinoma. (29th October 2011)

• Record Type: Journal Article
• Authors: Hwang, Sonya J.; Shroyer, Kenneth R.
• Other Names: Longatto-Filho Adhemar Academic Editor.
• Is Part Of: Journal of oncology. Volume 2012(2012)
• Publication Date: 2011-10-29
• Subjects: Oncology -- Research -- Periodicals; Tumors -- Periodicals; Neoplasms; Oncology -- Research; Tumors; Periodicals; Periodicals; 616.994
• DOI: 10.1155/2012/507286
• Languages: English
• ISSNs: 1687-8450

Abstract

Abstract : Although cervical cytology screening has decreased the incidence of cervical cancer in industrialized countries, HPV-related cervical disease, including premalignant and malignant lesions, continues to represent a major burden on the health care system. Some of the problems include the potential for either under- or overtreatment of women due to decreased specificity of screening tests as well as significant interobserver variability in the diagnosis of cervical dysplastic lesions. Although not completely elucidated, the HPV-driven molecular mechanisms underlying the development of cervical lesions have provided a number of potential biomarkers for both diagnostic and prognostic use in the clinical management of these women.