Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women. (9th July 2012)

• Record Type: Journal Article
• Authors: Blake-Gumbs, Lyla; Chen, Zhengyi; Thompson, Cheryl L.; Berger, Nathan A.; Tucker, Thomas C.; Li, Li
• Other Names: Fenton Jenifer I. Academic Editor.
• Is Part Of: Journal of obesity. Volume 2012(2012)
• Publication Date: 2012-07-09
• Subjects: Obesity -- Periodicals; Obesity; Obesity; Electronic journals; Periodicals; Periodicals; 616.398
• DOI: 10.1155/2012/857510
• Languages: English
• ISSNs: 2090-0708

Abstract

Abstract : Purpose . We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population. Methods . We included 1, 457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer. Results . We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with <5 kg/m 2 change of BMI, women who reported moderate (5–10 kg/m 2 ) and large (>10 kg/m 2 ) BMI changes since their 20s had OR estimates of 1.54 (95% CI = 1.09–2.19) and 1.45 (95% CI = 0.90–2.33), respectively ( P for trend = 0.05). Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95% CI = 1.02–3.05) and 2.21 (95% CI = 1.09–4.45), respectively ( P for trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users. Similar associations were observed for BMI changes since the 30s decade. There was no association among HRT users. Conclusion . Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT.