A Novel Nanocomposite Particle of Hydroxyapatite and Silk Fibroin: Biomimetic Synthesis and Its Biocompatibility. (5th August 2010)

• Record Type: Journal Article
• Authors: Niu, Lin; Zou, Rui; Liu, Qida; Li, Quanli; Chen, Xinmin; Chen, Zhiqing
• Other Names: Lin Gong Ru Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2010(2010)
• Publication Date: 2010-08-05
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2010/729457
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : A novel bone-like biomaterial of hydroxyapatite (HAP) and silk fibroin (SF) composite was developed by biomimetic synthesis. The composite was precipitated from drops of Ca( OH ) 2 suspension and H 3 PO 4 solution with SF. With this method, the HAP nanocrystals were obtained by self-assembling on a SF surface whose c-axis was aligned with the long-axis direction of SF in microstructures; this shares the same misconstrues of collagen and HAP with that in the natural bone. The HAP/SF composite then demonstrated that it could promote osteoblast proliferation in vitro and new bone formation in vivo . The novel biomaterial is a promising material for bone replacement and regeneration.