L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma. (23rd November 2011)

• Record Type: Journal Article
• Authors: Al-Biltagi, Mohammed; Isa, Mona; Bediwy, Adel Salah; Helaly, Nevien; El Lebedy, Dalia D.
• Other Names: Hogan Mary Beth Academic Editor.
• Is Part Of: Journal of allergy. Volume 2012(2012)
• Publication Date: 2011-11-23
• Subjects: Allergy -- Periodicals; Immunologic diseases -- Periodicals; Allergy and Immunology; Hypersensitivity; Immune System Diseases; Allergy; Immunologic diseases; Electronic journals; Periodical; Periodicals; 616.97
• DOI: 10.1155/2012/509730
• Languages: English
• ISSNs: 1687-9783

Abstract

Abstract : The objective . was to investigate L-Carnitine level and the effects of its supplementation in children with moderate persistent Asthma. Methods . Free and total serum carnitine levels were measured in 50 children having moderate persistent asthma and 50 healthy control children. The patients group was randomly divided into two subgroups. Subgroup A was supplemented with L-carnitine for 6 months while subgroup B was used as a placebo controls. Both subgroups were assessed by pulmonary function tests (PFT) and childhood-asthma control test (C-ACT) before and 6 months after carnitine supplementation. Results . Total and free carnitine levels were significantly lower in patient group than in control group. PFT and C-ACT showed significant improvements in asthmatic children supplemented with L-carnitine than in those who were not supplemented. Conclusion . L-carnitine levels were initially lower in moderate persistent asthmatic children as compared to healthy control children. Asthmatic children who received L-carnitine supplementation showed statistically significant improvement of C-ACT and PFT.