(R)-α-Aminoadipic Acid: A Versatile Precursor for the Synthesis of D-Amino Acids. (10th October 2013)

• Record Type: Journal Article
• Authors: Sadiq, Amina; Sewald, Norbert
• Other Names: Kotha Sambasivarao Academic Editor.
• Is Part Of: Journal of amino acids. Volume 2013(2013)
• Publication Date: 2013-10-10
• Subjects: Amino acids -- Periodicals; Amino Acids; Amino acids; Electronic journals; Periodical; Periodicals; 612.015756
• DOI: 10.1155/2013/252813
• Languages: English
• ISSNs: 2090-0404

Abstract

Abstract : The ready accessibility of ( R )- α -aminoadipic acid by enzymatic cleavage of cephalosporin C (CephC) in the production of 7-aminocephalosporanic acid (7-ACA) on a large scale makes it a favorable chiral pool building block for the synthesis of unusual amino acids. A route for the synthesis of C-5-alkenyl and C-6-alkylidene derivatives of ( R )-pipecolic acid is described which utilizes ( R )- α -aminoadipic acid as the enantiomerically pure starting material. Moreover, the synthesis of azido and triazolyl derivatives of ( R )- α -aminoadipic acid is reported.