Socioeconomic risk factors and age-related macular degeneration in the UK Biobank study. Issue 1 (23rd February 2021)

• Record Type: Journal Article
• Authors: Yip, Jennifer Lai Yee; Muthy, Zaynah; Peto, Tunde; Lotery, Andrew; Foster, Paul J; Patel, Praveen
• Other Names: author non-byline.; Aslam Tariq author non-byline.; Barman Sarah author non-byline.; Barrett Jenny author non-byline.; Bishop Paul author non-byline.; Blows Peter author non-byline.; Carare Roxana author non-byline.; Bunce Catey author non-byline.; Chakravarthy Usha author non-byline.; Chan Michelle author non-byline.; Chua Sharon author non-byline.; Crabb David author non-byline.; Cumberland Philippa author non-byline.; Day Alexander author non-byline.; Desai Parul author non-byline.; Dhillon Bal author non-byline.; Dick Andrew author non-byline.; Egan Cathy author non-byline.; Ennis Sarah author non-byline.; Fruttiger Marcus author non-byline.; Gallacher John author non-byline.; Garway-Heath David author non-byline.; Gibson Jane author non-byline.; Gore Dan author non-byline.; Guggenheim Jeremy author non-byline.; Hammond Chris author non-byline.; Hardcastle Alison author non-byline.; Harding Simon author non-byline.; Hogg Ruth author non-byline.; Hysi Pirro author non-byline.; Keane Pearse author non-byline.; Khaw Sir author non-byline.; Khawaja Anthony author non-byline.; Lascaratos Gerassimos author non-byline.; Luthert Phil author non-byline.; Macgillivray Tom author non-byline.; Mackie Sarah author non-byline.; Martin Keith author non-byline.; Mcgaughey Michelle author non-byline.; Mcguinness Bernadette author non-byline.; Mckibbin Martin author non-byline.; Mitry Danny author non-byline.; Moore Tony author non-byline.; Morgan James author non-byline.; Muthy Zaynah author non-byline.; O'sullivan Eoin author non-byline.; Owen Chris author non-byline.; Patel Praveen author non-byline.; Paterson Euan author non-byline.; Peto Tunde author non-byline.; Petzold Axel author non-byline.; Rahi Jugnoo author non-byline.; Rudnicka Alicja author non-byline.; Self Jay author non-byline.; Sivaprasad Sobha author non-byline.; Steel David author non-byline.; Stratton Irene author non-byline.; Strouthidis Nicholas author non-byline.; Sudlow Cathie author non-byline.; Thaung Caroline author non-byline.; Thomas Dhanes author non-byline.; Trucco Emanuele author non-byline.; Tufail Adnan author non-byline.; Vitart Veronique author non-byline.; Vernon Stephen author non-byline.; Viswanathan Ananth author non-byline.; Williams Cathy author non-byline.; Williams Katie author non-byline.; Woodside Jayne author non-byline.; Yates Max author non-byline.; Zheng Yalin author non-byline.;
• Is Part Of: BMJ open ophthalmology. Volume 6:Issue 1(2021)
• Publication Date: 2021-02-23
• Subjects: retina -- public health -- epidemiology -- degeneration -- epidemiology; Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1136/bmjophth-2020-000585
• Languages: English
• ISSNs: 2397-3269

Abstract

Abstract : Objective: There is contrasting evidence on the relationship between socioeconomic status (SES) and age-related macular degeneration (AMD), the most common cause of visual impairment (VI) in developed countries. This study examines the relationship between SES, cardiovascular risk factors and self-reported AMD. Methods and analysis: Over 500000 people participated in the UK Biobank study from 2006 to 2019, with sociodemographic data and clinical measurements collected using standardised procedures. Visual acuity was measured in 117907 participants with VI defined as LogMAR ≤0.3. We used logistic regression to examine the cross-sectional associations between SES and self-reported AMD. Results: Self-reported AMD was available for 133339 participants aged 50 and older. People reporting AMD had higher academic qualifications, lower income, were unable to work due to disability, have higher BMI, diabetes and vascular heart disease after adjusting for age and sex. In a multivariable analysis, higher income was protective of AMD and economic inactivity due to disability increased the odds of AMD (2.02, 95% CI 1.13 to 3.61). Both associations were independent of cardiovascular factors, but was no longer significant after adjusting for VI. Conclusions: The association between education, employment and household income with AMD was independent of cardiovascular risk factors.