Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected with Leishmania donovani. (21st July 2011)

• Record Type: Journal Article
• Authors: Bankoti, Rashmi; Stäger, Simona
• Other Names: Engwerda Christian Academic Editor.
• Is Part Of: Journal of tropical medicine. Volume 2012(2012)
• Publication Date: 2011-07-21
• Subjects: Tropical medicine -- Periodicals; 616.9883
• DOI: 10.1155/2012/639304
• Languages: English
• ISSNs: 1687-9686

Abstract

Abstract : Immunity to pathogens requires generation of effective innate and adaptive immune responses. Leishmania donovani evades these host defense mechanisms to survive and persist in the host. A better understanding and identification of mechanisms that L. donovani employs for its survival is critical for developing novel therapeutic interventions that specifically target the parasite. This paper will highlight some of the mechanisms that the parasite utilizes for its persistence and also discuss how the immune response is regulated.