Comparison of Carotid Intima-Media Thickness in Pediatric Patients with Metabolic Syndrome, Heterozygous Familial Hyperlipidemia and Normals. (14th May 2014) - Vijayasarathi, Arvind
Abstract : Background. Our goal was to compare the carotid intimal-medial thickness (CIMT) of untreated pediatric patients with metabolic syndrome (MS), heterozygous familial hyperlipidemia (heFH), and MS+heFH against one another and against a control group consisting of healthy, normal body habitus children. Methods. Our population consisted of untreated pediatric patients (ages 5–20 yrs) who had CIMT measured in a standardized manner. Results. Our population included 57 with MS, 23 with heFH, and 10 with MS+heFH. The control group consisted of 84 children of the same age range. Mean CIMT for the MS group was 469.8 μ m (SD = 67), 443.8 μ m (SD = 61) for the heFH group, 478.3 μ m (SD = 70) for the MS+heFH group, and 423.2 μ m (SD = 45) for the normal control group. Significance differences between groups occurred for heFH versus MS ( P = 0.022 ), heFH versus control ( P = 0.038 ), MS versus control ( P = 9.0 E - 10 ), and MS+heFH versus control ( P = 0.003 ) . Analysis showed significant negative correlation between HDL and CIMT ( r = - 0.32, P = 0.03 ) but not for LDL, triglycerides, BP, waist circumference, or BMI. Conclusion. For pediatric patients, the thickest CIMT occurred for patients with MS alone or for those with MS+heFH. This indicates that MS, rather than just elevated LDL, accounts for more rapid thickening of CIMT in this population.