Recent developments in microfluidic chip-based separation devices coupled to MS for bioanalysis. (October 2013)

• Record Type: Journal Article
• Authors: Lin, Shu-Ling; Lin, Tzuen-Yeuan; Fuh, Ming-Ren
• Is Part Of: Bioanalysis. Volume 5:Number 20(2013)
• Page Start: 2567
• Page End: 2580
• Publication Date: 2013-10
• Subjects: Drugs -- Analysis -- Periodicals; 615.19005
• DOI: 10.4155/bio.13.196
• Languages: English
• ISSNs: 1757-6180

Abstract

In recent years, the development of microfluidic chip separation devices coupled to MS has dramatically increased for high-throughput bioanalysis. In this review, advances in different types of microfluidic chip separation devices, such as electrophoresis- and LC-based microchips, as well as 2D design of microfluidic chip-based separation devices will be discussed. In addition, the utilization of chip-based separation devices coupled to MS for analyzing peptides/proteins, glycans, drug metabolites and biomarkers for various bioanalytical applications will be evaluated.