Correlation between baseline retinal microstructures in spectral-domain optic coherence tomography and need for early intervention in central serous chorioretinopathy. Issue 1 (16th August 2017)

• Record Type: Journal Article
• Authors: Lai, Wei-Yu; Tseng, Cheui-Lien; Wu, Tsung-Tien; Lin, Huey-Shyan; Sheu, Shwu-Jiuan
• Is Part Of: BMJ open ophthalmology. Volume 2:Issue 1(2017)
• Publication Date: 2017-08-16
• Subjects: central serous chorioretinopathy -- intervention -- optical coherence tomography (OCT); Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1136/bmjophth-2016-000054
• Languages: English
• ISSNs: 2397-3269

Abstract

Abstract : Purpose: To investigate the association between baseline retinal microstructures observed with spectral-domain optical coherence tomography (OCT) and the need for early intervention in central serous chorioretinopathy (CSC). Methods: Cases of acute CSC from July 2011 to December 2014 were retrospectively reviewed. OCT images were further classified using six parameters: foveal serous retinal detachment; pigment epithelial detachment; fibrinous exudates in the subretinal space; retinal pigment epithelium bumps; thickened outer retinal layer and hyper-reflective dots in the intraretinal and/or subretinal layer. Correlation among these parameters and the need for intervention was analysed. Receiver operating characteristic (ROC) curves were performed to identify the optimal number of parameters for prediction. Results: A total of 47 eyes from 47 patients were included. Among these, 25 eyes required treatment. The presence of subretinal hyper-reflective dots was the only OCT factor having significant association with the need for intervention. An ROC curve analysis revealed that the optimal cut-off value (Youden index) was achieved when combining subretinal hyper-reflective dots with aged ≥50 years and female sex for analysis (area under the curve, 0.735; Youden index: 0.425). Conclusion: The presence of subretinal/intraretinal hyper-reflective dots observed with OCT, female and aged ≥50 years might help predict the need for early intervention in acute CSC.