Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury. (28th June 2012)

• Record Type: Journal Article
• Authors: Peng, Yu; Li, Qiang; Zhang, Lu; Bai, Ming; Zhang, Zheng
• Other Names: Drew Paul Academic Editor.
• Is Part Of: PPAR research. Volume 2012(2012)
• Publication Date: 2012-06-28
• Subjects: Peroxisomes -- Periodicals; Peroxisomal disorders -- Periodicals; 571.65505
• DOI: 10.1155/2012/970525
• Languages: English
• ISSNs: 1687-4757

Abstract

Abstract : Peroxisome proliferator-activated receptor α is a member of the nuclear receptor superfamily. It modulates smooth muscle cell proliferation and inflammatory cytokines in vitro. In this study, we tested the hypothesis that PPAR α would decrease the expression of monocyte chemoattractant protein-1 and tissue factor, and inhibit neointimal formation in a murine double carotid artery injury model. Carotid artery injury was performed in the PPAR α knockout and wild type (WT) mice, treated and untreated with Wy14643, a PPAR α activator. Up-regulated MCP-1 and TF expression and more neointimal formation were observed in the PPAR α −/− mice compared with WT mice. The activation of PPAR α resulted in further decreased neointimal formation. Our data further suggest that the decrease in neointimal formation is due to down-regulation of MCP-1 by PPAR α resulting in decreased leukocyte infiltration and TF expression.