Circular RNAs in the Brain: A Possible Role in Memory?. (October 2021)

• Record Type: Journal Article
• Authors: Zajaczkowski, Esmi L.; Bredy, Timothy W.
• Is Part Of: Neuroscientist. Volume 27:Number 5(2021)
• Page Start: 473
• Page End: 486
• Publication Date: 2021-10
• Subjects: circRNA -- translation -- RNA transfer -- learning -- memory -- synapse; Neurosciences -- Periodicals; Neurology -- Periodicals; Neurobiology -- Periodicals; 616.8005
• DOI: 10.1177/1073858420963028
• Languages: English
• ISSNs: 1073-8584

Abstract

Higher-order organisms possess information processing capabilities that are only made possible by their biological complexity. Emerging evidence indicates a critical role for regulatory RNAs in coordinating many aspects of cellular function that are directly involved in experience-dependent neural plasticity. Here, we focus on a structurally distinct class of RNAs known as circular RNAs. These closed loop, single-stranded RNA molecules are highly stable, enriched in the brain, and functionally active in both healthy and disease conditions. Current evidence implicating this ancient class of RNA as a contributor toward higher-order functions such as cognition and memory is discussed.