Response to Acute Psychophysical Stress and 24-Hour Glycemic Control in Healthy Older People. (8th July 2012)

• Record Type: Journal Article
• Authors: DiPietro, Loretta; Yeckel, Catherine W.; Gribok, Andrei
• Other Names: Nose Hiroshi Academic Editor.
• Is Part Of: Journal of aging research. Volume 2012(2012)
• Publication Date: 2012-07-08
• Subjects: Aging -- Periodicals; Aging -- Research -- Periodicals; 612.6705
• DOI: 10.1155/2012/803864
• Languages: English
• ISSNs: 2090-2204

Abstract

Abstract : We examined the relation between stress reactivity and 24 h glycemic control in 17 inactive, healthy older people (≥60 years) under both a novel psychophysical stress and a seated control condition. Plasma cortisol was measured over the course of the stress and recovery periods. Glycemic control was determined over the subsequent 3 h from an oral glucose tolerance test (OGTT) and over 24 h via continuous glucose monitoring (CGM). We observed significant (P < 0.05 ) elevations in perceived stress, cardiovascular activity, and peak cortisol response at 30 min (10.6 ± 3.1 versus 8.6 ± 2.6 μ g·dL −1, resp.) during the stress compared with the control condition; however, 3 h OGTT glucose and insulin responses were similar between conditions. The CGM data suggested a 30–40 min postchallenge delay in peak glucose response and attenuated glucose clearance over the 6 h following the stress condition, but these alterations were not statistically significant. Healthy older people may demonstrate minimal disruption in metabolic resiliency following everyday psychological stress.