Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy. (25th May 2021)

• Record Type: Journal Article
• Authors: Sharifian, Maedeh; Rezaeian, Nahid; Asadian, Sanaz; Mohammadzadeh, Ali; Nahardani, Ali; Kasani, Kianosh; Toloueitabar, Yaser; Farahmand, Ali Mohammad; Hosseini, Leila
• Other Names: Tse Gary Academic Editor.
• Is Part Of: Cardiology research and practice. Volume 2021(2021)
• Publication Date: 2021-05-25
• Subjects: Cardiology -- Research -- Periodicals; Cardiology -- Periodicals; Cardiology; Cardiology; Cardiology -- Research; Electronic journals; Periodicals; Periodicals; 616.12
• DOI: 10.1155/2021/9931136
• Languages: English
• ISSNs: 2090-8016

Abstract

Abstract : Objective . In hypertrophic cardiomyopathy (HCM), myocardial fibrosis is routinely shown by late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) imaging. We evaluated the efficacy of 2 novel contrast-free CMR methods, namely, diffusion-weighted imaging (DWI) and feature-tracking (FT) method, in detecting myocardial fibrosis. Methods . This cross-sectional study was conducted on 26 patients with HCM. Visual and quantitative comparisons were made between DWI and LGE images. Regional longitudinal, circumferential, and radial strains were compared between LGE-positive and LGE-negative segments. Moreover, global strains were compared between LGE-positive and LGE-negative patients as well as between patients with mild and marked LGE. Results . All 3 strains showed significant differences between LGE-positive and LGE-negative segments (P < 0.001 ). The regional longitudinal and circumferential strain parameters showed significant associations with LGE (P < 0.001 ), while regional circumferential strain was the only independent predictor of LGE in logistic regression models (OR: 1.140, 95% CI: 1.073 to 1.207, P < 0.001 ). A comparison of global strains between patients with LGE percentages of below 15% and above 15% demonstrated that global circumferential strain was the only parameter to show impairment in the group with marked myocardial fibrosis, with borderline significance (P = 0.09 ). A review of 212 segments demonstrated a qualitative visual agreement between DWI and LGE in 193 segments (91%). The mean apparent diffusion coefficient was comparable between LGE-positive and LGE-negative segments (P = 0.51 ). Conclusions . FT-CMR, especially regional circumferential strain, can reliably show fibrosis-containing segments in HCM. Further, DWI can function as an efficient qualitative method for the estimation of the fibrosis extent in HCM.