Transcriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin Sensitivity. (6th December 2012)

• Record Type: Journal Article
• Authors: Qi, Zhengtang; Ding, Shuzhe
• Other Names: Yamaguchi Tetsuo Academic Editor.
• Is Part Of: PPAR research. Volume 2012(2012)
• Publication Date: 2012-12-06
• Subjects: Peroxisomes -- Periodicals; Peroxisomal disorders -- Periodicals; 571.65505
• DOI: 10.1155/2012/348245
• Languages: English
• ISSNs: 1687-4757

Abstract

Abstract : The peroxisome proliferator-activated receptors (PPARs) and estrogen-related receptor (ERR α ) are ligand-activated nuclear receptors that coordinately regulate gene expression. Recent evidence suggests that nuclear corepressors, NCoR, RIP140, and SMRT, repress nuclear receptors-mediated transcriptional activity on specific promoters, and thus regulate insulin sensitivity, adipogenesis, mitochondrial number, and activity in vivo. Moreover, the coactivator PGC-1 α that increases mitochondrial biogenesis during exercise and calorie restriction directly regulates autophagy in skeletal muscle and mitophagy in the pathogenesis of Parkinson's disease. In this paper, we discuss the PGC-1 α 's novel role in mitochondrial quality control and the role of nuclear corepressors in regulating insulin sensitivity and interacting with PGC-1 α .