Caucasian and Asian difference in role of type 1 diabetes on large-for-gestational-age neonates. Issue 2 (19th November 2020)

• Record Type: Journal Article
• Authors: Guo, Yanfang; Luo, Rong; Corsi, Daniel J; Retnakaran, Ravi; Walker, Mark C; Wen, Shi Wu
• Is Part Of: BMJ open diabetes research and care. Volume 8:Issue 2(2020)
• Publication Date: 2020-11-19
• Subjects: pregnancy outcome -- retrospective studies -- diabetes mellitus -- type 1 -- epidemiology; Diabetes -- Periodicals; 616.462005
• DOI: 10.1136/bmjdrc-2020-001746
• Languages: English
• ISSNs: 2052-4897

Abstract

Abstract : Introduction: Racial differences in the association between type 1 diabetes mellitus (T1DM) and large-for-gestational-age (LGA) neonates remain unclear. The objective of this study was to compare the effect of T1DM on LGA neonates between Caucasian and Asian women. Research design and methods: A population-based retrospective cohort study was conducted among Caucasian and Asian women who had prenatal screening and gave a singleton live birth in an Ontario hospital between April 2015 and March 2018. Multivariable log-binomial regression models were used to estimate the adjusted relative risks (aRRs) and 95% CIs of T1DM on LGA for Caucasian and Asian women. Relative contribution of T1DM to LGA was examined by multivariable logistic regression model, stratified by Caucasian and Asian women. Results: A total of 232 503 women (69.4% Caucasians and 30.6% Asians) were included in the final analysis. The rate of T1DM was higher in Caucasians (0.5%) than in Asians (0.2%), and the rate of LGA neonates was also higher in Caucasians (11.0%) than in Asians (5.0%). The association between T1DM and LGA in Caucasians (aRR 4.18, 95% CI (3.84 to 4.55)) was more robust than that in Asians (aRR 2.11, 95% CI (1.24 to 3.59)). T1DM was the fourth strongest contributor to LGA in Caucasians, while T1DM was the seventh contributor to LGA in Asians. Conclusions: T1DM plays a more substantial role in LGA among Caucasians than Asians. Clinicians should be aware of the Caucasian–Asian differences of effects of T1DM on LGA when developing pregnancy management strategies.