Pharmacokinetics of meropenem during advanced organ support (ADVOS®) and continuous renal replacement therapy. Issue 10 (October 2021)

• Record Type: Journal Article
• Authors: König, Christina; Kluge, Stefan; Fuhrmann, Valentin; Jarczak, Dominik
• Is Part Of: International journal of artificial organs. Volume 44:Issue 10(2021)
• Page Start: 783
• Page End: 786
• Publication Date: 2021-10
• Subjects: Pharmacokinetic -- artificial kidney -- apheresis and detoxification techniques -- liver failure -- solute kinetics in dialysis -- antibiotics; Artificial organs -- Periodicals; 617.956
• DOI: 10.1177/03913988211021101
• Languages: English
• ISSNs: 0391-3988

Abstract

The advanced organ support (ADVOS) system allows to eliminate water-soluble as well as protein-bound molecules. Despite its clinical features, to date nothing is known about the elimination of clinically relevant drugs such as antiinfectives. Therefore, we report a case treated with ADVOS, continuous renal replacement therapy (CRRT), and meropenem (1 g 8-hourly) for empiric sepsis therapy monitored by meropenem drug levels. ADVOS showed more efficient elimination of meropenem compared to CRRT which has to be considered when evaluating dosing regimens.