Catalase Influence in the Regulation of Coronary Resistance by Estrogen: Joint Action of Nitric Oxide and Hydrogen Peroxide. (6th February 2014)

• Record Type: Journal Article
• Authors: Schenkel, Paulo C.; Fernandes, Rafael O.; Viegas, Vinícius U.; Campos, Cristina; Fernandes, Tânia R. G.; Araujo, Alex Sander da Rosa; Belló-Klein, Adriane
• Other Names: Khaper Neelam Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2014(2014)
• Publication Date: 2014-02-06
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2014/159852
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : We tested the influence of estrogen on coronary resistance regulation by modulating nitric oxide (NO) and hydrogen peroxide (H2 O2 ) levels in female rats. For this, estrogen levels were manipulated and the hearts were immediately excised and perfused at a constant flow using a Langendorff's apparatus. Higher estrogen levels were associated with a lower coronary resistance, increased nitric oxide bioavailability, and higher levels of H2 O2 . When oxide nitric synthase blockade by L-NAME was performed, no significant changes were found in coronary resistance of ovariectomized rats. Additionally, we found an inverse association between NO levels and catalase activity. Taken together, our data suggest that, in the absence of estrogen influence and, therefore, reduced NO bioavailability, coronary resistance regulation seems to be more dependent on the H2 O2 that is maintained at low levels by increased catalase activity.