Routine use of natriuretic peptides: Lessons from a big data analysis. (September 2021)

• Record Type: Journal Article
• Authors: Goudot, FX; Msadek, S; Boukertouta, T; Schischmanoff, PO; Meune, C
• Is Part Of: Annals of clinical biochemistry. Volume 58:Number 5(2021)
• Page Start: 481
• Page End: 486
• Publication Date: 2021-09
• Subjects: Natriuretic peptide -- NT-proBNP -- routine use -- misuse -- big-data; Clinical chemistry -- Periodicals; Clinical biochemistry -- Periodicals; 616.075
• DOI: 10.1177/00045632211020779
• Languages: English
• ISSNs: 0004-5632

Abstract

Background: Natriuretic peptides have broad indications during heart failure and the detection of left ventricular dysfunction in high-risk patients. They can also be used for the diagnosis/management of other cardiac diseases. However, very little is known regarding their use in routine practice. Methods: We examined all biological tests performed from February 2010 to August 2015 in two districts from the French Brittany, covering 13, 653 km 2 and including 22, 265 physicians. We report the settings and conditions of N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurements (the only locally natriuretic peptide available). Results: From a total of 3, 606, 432 tests requested in 557, 650 adult (older than 20 years) patients, only 56, 653 (1.6%) included at least one NT-proBNP measurement. NT-proBNP measurements gradually increased, from 9188 in 2011 to 12, 938 in 2014 ( P < 0.001). Most NT-proBNP tests were measured in urban laboratories (72.7%) and in private (62.9%) non-hospital/clinics laboratories; they were mostly ordered by general practitioners (66% compared with 11% by cardiologists). The number of NT-proBNP measurements increased with age up to 80–90 years, and 70.3% of tests were measured in ≥75 years patients. Creatinine and electrolytes were not associated with NT-proBNP in 15.8% and 19.7% of tests, respectively. Conclusion: Among a very large cohort, we observed that natriuretic peptides remain largely undermeasured. NT-proBNP is mostly measured in elderly patients, and its interpretation may be hazardous in up to 16% of all individuals because no measurement of creatinine was associated to NT-proBNP.