Sleep apnoea is a risk factor for severe COVID-19. Issue 1 (12th January 2021)

• Record Type: Journal Article
• Authors: Strausz, Satu; Kiiskinen, Tuomo; Broberg, Martin; Ruotsalainen, Sanni; Koskela, Jukka; Bachour, Adel; Palotie, Aarno; Palotie, Tuula; Ripatti, Samuli; Ollila, Hanna M.
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Whelan Christopher author non-byline.; Xu Fanli author non-byline.; Pulford David author non-byline.; Färkkilä Martti author non-byline.; Pikkarainen Sampsa author non-byline.; Jussila Airi author non-byline.; Blomster Timo author non-byline.; Kiviniemi Mikko author non-byline.; Voutilainen Markku author non-byline.; Georgantas Bob author non-byline.; Heap Graham author non-byline.; Waring Jeffrey author non-byline.; Smaoui Nizar author non-byline.; Rahimov Fedik author non-byline.; Lehtonen Anne author non-byline.; Usiskin Keith author non-byline.; Maranville Joseph author non-byline.; Lu Tim author non-byline.; Bowers Natalie author non-byline.; Oh Danny author non-byline.; Michon John author non-byline.; Mehta Vinay author non-byline.; Kalpala Kirsi author non-byline.; Miller Melissa author non-byline.; Hu Xinli author non-byline.; McCarthy Linda author non-byline.; Eklund Kari author non-byline.; Palomäki Antti author non-byline.; Isomäki Pia author non-byline.; Pirilä Laura author non-byline.; Kaipiainen-Seppänen Oili author non-byline.; Huhtakangas Johanna author non-byline.; Georgantas Bob author non-byline.; Waring Jeffrey author non-byline.; Rahimov Fedik author non-byline.; Lertratanakul Apinya author non-byline.; Smaoui Nizar author non-byline.; Close David author non-byline.; Hochfeld Marla author non-byline.; Bowers Natalie author non-byline.; Michon John author non-byline.; Diogo Dorothee author non-byline.; Mehta Vinay author non-byline.; Kalpala Kirsi author non-byline.; Bing Nan author non-byline.; Hu Xinli author non-byline.; Gordillo Jorge Esparza author non-byline.; Mars Nina author non-byline.; Laitinen Tarja author non-byline.; Pelkonen Margit author non-byline.; Kauppi Paula author non-byline.; Kankaanranta Hannu author non-byline.; Harju Terttu author non-byline.; Smaoui Nizar author non-byline.; Close David author non-byline.; GreenbergCelgene Steven author non-byline.; Chen Hubert author non-byline.; Bowers Natalie author non-byline.; Michon John author non-byline.; 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Davis Justin author non-byline.; Riley-Gillis Bridget author non-byline.; Quarless Danjuma author non-byline.; Petrovski Slavé author non-byline.; Liu Jimmy author non-byline.; Chen Chia-Yen author non-byline.; Bronson Paola author non-byline.; Yang Robert author non-byline.; Maranville Joseph author non-byline.; Biswas Shameek author non-byline.; Chang Diana author non-byline.; Hunkapiller Julie author non-byline.; Bhangale Tushar author non-byline.; Bowers Natalie author non-byline.; Diogo Dorothee author non-byline.; Holzinger Emily author non-byline.; Gormley Padhraig author non-byline.; Wang Xulong author non-byline.; Chen Xing author non-byline.; Hedman Åsa author non-byline.; Auro Kirsi author non-byline.; Wang Clarence author non-byline.; Xu Ethan author non-byline.; Auge Franck author non-byline.; Chatelain Clement author non-byline.; Kurki Mitja author non-byline.; Ripatti Samuli author non-byline.; Daly Mark author non-byline.; Karjalainen Juha author non-byline.; Havulinna Aki author non-byline.; Jalanko Anu author non-byline.; Palin Kimmo author non-byline.; Palta Priit author non-byline.; Della Pietro author non-byline.; Zhou Wei author non-byline.; Lemmelä Susanna author non-byline.; Rivas Manuel author non-byline.; Harju Jarmo author non-byline.; Palotie Aarno author non-byline.; Lehisto Arto author non-byline.; Ganna Andrea author non-byline.; Llorens Vincent author non-byline.; Karlsson Antti author non-byline.; Kristiansson Kati author non-byline.; Arvas Mikko author non-byline.; Hyvärinen Kati author non-byline.; Ritari Jarmo author non-byline.; Wahlfors Tiina author non-byline.; Koskinen Miika author non-byline.; Carpen Olli author non-byline.; Kettunen Johannes author non-byline.; Pylkäs Katri author non-byline.; Kalaoja Marita author non-byline.; Karjalainen Minna author non-byline.; Mantere Tuomo author non-byline.; Kangasniemi Eeva author non-byline.; Heikkinen Sami author non-byline.; Mannermaa Arto author non-byline.; Laakkonen Eija author non-byline.; Kononen Juha author non-byline.; 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Kiiskinen Tuomo author non-byline.; Laitinen Tarja author non-byline.; Siirtola Harri author non-byline.; Tabuenca Javier author non-byline.; Kallio Lila author non-byline.; Soini Sirpa author non-byline.; Partanen Jukka author non-byline.; Pitkänen Kimmo author non-byline.; Vainio Seppo author non-byline.; Savinainen Kimmo author non-byline.; Kosma Veli-Matti author non-byline.; Kuopio Teijo author non-byline.;
• Is Part Of: BMJ open respiratory research. Volume 8:Issue 1(2021)
• Publication Date: 2021-01-12
• Subjects: sleep apnoea -- COVID-19; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Diseases -- Treatment -- Periodicals; Respiratory therapy -- Periodicals; 616.2005
• DOI: 10.1136/bmjresp-2020-000845
• Languages: English
• ISSNs: 2052-4439

Abstract

Abstract : Background: Obstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19. We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19. Methods: OSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and infectious diseases registries in individuals who participated in the FinnGen study (n=260 405). Severe COVID-19 was defined as COVID-19 requiring hospitalisation. Multivariate logistic regression model was used to examine association. Comorbidities for either COVID-19 or OSA were selected as covariates. We performed a meta-analysis with previous studies. Results: We identified 445 individuals with COVID-19, and 38 (8.5%) of them with OSA of whom 19 out of 91 (20.9%) were hospitalised. OSA associated with COVID-19 hospitalisation independent from age, sex, BMI and comorbidities (p-unadjusted=5.13×10 −5, OR-adjusted=2.93 (95% CI 1.02 to 8.39), p-adjusted=0.045). OSA was not associated with the risk of contracting COVID-19 (p=0.25). A meta-analysis of OSA and severe COVID-19 showed association across 15 835 COVID-19 positive controls, and n=1294 patients with OSA with severe COVID-19 (OR=2.37 (95% 1.14 to 4.95), p=0.021). Conclusion: Risk for contracting COVID-19 was the same for patients with OSA and those without OSA. In contrast, among COVID-19 positive patients, OSA was associated with higher risk for hospitalisation. Our findings are in line with earlier works and suggest OSA as an independent risk factor for severe COVID-19.