Multispectral photoacoustic imaging of cancer with broadband CuS nanoparticles covering both near‐infrared I and II biological windows. Issue 3 (9th December 2018)

• Record Type: Journal Article
• Authors: Liu, Yubin; Gao, Duyang; Xu, Mengze; Yuan, Zhen
• Is Part Of: Journal of biophotonics. Volume 12:Issue 3(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-09
• Subjects: CuS nanoparticles -- multispectral -- NIR‐II biological windows -- photoacoustic imaging -- quantitative imaging; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201800237
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : In this study, CuS nanoparticles with optical absorption covering both near‐infrared I (NIR‐I) and NIR‐II biological windows were prepared and served as the contrast agents for multispectral photoacoustic imaging. The physiological parameters including concentrations of deoxyhemoglobin and oxyhemoglobin as well as the water content in the tumor location were quantified based on the multispectral photoacoustic reconstruction method. More importantly, the concentration of CuS nanoparticles/drugs accumulated in the tumor was also recovered after intravenously injection, which are essential for image‐guided cancer theranostics. In addition, phantom and in vivo experimental tests were performed to inspect and compare the imaging depth and signal‐to‐noise ratio (SNR) between the two NIR biological windows. Interestingly, we discovered that a higher SNR was obtained in the NIR‐II window than that in the NIR‐I window. Meanwhile, the multispectral imaging results also demonstrated that the imaging contrast and penetration depth in the NIR‐II window were also significantly improved as compared to those from the NIR‐I window. Abstract : Fig. Quantitative multispectral photoacoustic molecular imaging of tumors based on broadband CuS nanoparticles covering both NIR‐I and NIR‐II biological windows. The as‐prepared CuS nanoparticles with broadband absorbing covering both NIR‐I and NIR‐II biological windows, which can be used to recover the physiology parameters and concurrently increase the imaging contrast based on the quantitative multispectral photoacoustic imaging technique.