Polyol Pathway Exacerbated Ischemia/Reperfusion-Induced Injury in Steatotic Liver. (20th May 2014)
- Record Type:
- Journal Article
- Title:
- Polyol Pathway Exacerbated Ischemia/Reperfusion-Induced Injury in Steatotic Liver. (20th May 2014)
- Main Title:
- Polyol Pathway Exacerbated Ischemia/Reperfusion-Induced Injury in Steatotic Liver
- Authors:
- Zhang, Changhe
Huang, Changjun
Tian, Yuan
Li, Xiangcheng - Other Names:
- Dal-Pizzol Felipe Academic Editor.
- Abstract:
- Abstract : Background . The polyol pathway, a bypass pathway of glucose metabolism initiated by aldose reductase (AR), has been shown to play an important role in mediating tissue ischemia/reperfusion (I/R) impairment recently. Here, we investigated how and why this pathway might affect the fatty liver following I/R. Methods . Two opposite models were created: mice with high-fat-diet-induced liver steatosis were treated with aldose reductase inhibition (ARI) and subsequent I/R; and AR-overexpressing L02 hepatocytes were sequentially subjected to steatosis and hypoxia/reoxygenation. We next investigated (a) the hepatic injuries, including liver function, histology, and hepatocytes apoptosis/necrosis; (b) the NAD(P)(H) contents, redox status, and mitochondrial function; and (c) the flux through the caspase-dependent apoptosis pathway. Results . AR-inhibition in vivo markedly attenuated the I/R-induced liver injuries, maintained the homeostasis of NAD(P)(H) contents and redox status, and suppressed the caspase-dependent apoptosis pathway. Correspondingly, AR overexpression in vitro presented the opposite effects. Conclusion . The flux through the polyol pathway may render steatotic liver greater vulnerability to I/R. Interventions targeting this pathway might provide a novel adjunctive approach to protect fatty liver from ischemia.
- Is Part Of:
- Oxidative medicine and cellular longevity. Volume 2014(2014)
- Journal:
- Oxidative medicine and cellular longevity
- Issue:
- Volume 2014(2014)
- Issue Display:
- Volume 2014, Issue 2014 (2014)
- Year:
- 2014
- Volume:
- 2014
- Issue:
- 2014
- Issue Sort Value:
- 2014-2014-2014-0000
- Page Start:
- Page End:
- Publication Date:
- 2014-05-20
- Subjects:
- Oxidative stress -- Periodicals
Cells -- Aging -- Periodicals
Cells -- Aging
Oxidative stress
Oxidative Stress -- Periodicals
Cell Aging -- Periodicals
Periodicals
611.0181 - Journal URLs:
- https://www.hindawi.com/journals/omcl/ ↗
- DOI:
- 10.1155/2014/963629 ↗
- Languages:
- English
- ISSNs:
- 1942-0900
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 17043.xml