Stimulus-specificity in the responses of immune sentinel cells. Issue 18 (December 2019)

• Record Type: Journal Article
• Authors: Sheu, Katherine M.; Luecke, Stefanie; Hoffmann, Alexander
• Is Part Of: Current opinion in systems biology. Issue 18(2019)
• Page Start: 53
• Page End: 61
• Publication Date: 2019-12
• Subjects: Innate immune signaling -- Transcriptomics -- Stimulus-specificity -- Immune responses -- Combinatorial coding -- Temporal coding -- Dynamics -- PRRs -- Transcription factors; Systems biology -- Periodicals; 570
• DOI: 10.1016/j.coisb.2019.10.011
• Languages: English
• ISSNs: 2452-3100

Abstract

Abstract: Innate immune sentinel cells must initiate and orchestrate appropriate immune responses for myriad pathogens. These stimulus-specific gene expression responses are mediated by combinatorial and temporal coding within a handful of immune response signaling pathways. We outline the scope of our current understanding and indicate pressing outstanding questions. Highlights: Innate immune sentinel cells produce stimulus-specific gene expression programs. Stimuli are encoded in combinations and temporal patterns of signaling activity. How response genes decode combinatorial and temporal activity is a research focus. The capacity of cells for stimulus-specific responses has not been quantified. How the tissue microenvironment affects coding capacities is of great interest.