Does complete deficiency of muscle α actinin 3 alter functional capacity in elderly women? A preliminary report. Issue 1 (21st December 2005)

• Record Type: Journal Article
• Authors: San Juan, A F; Gomez-Gallego, F; Cañete, S; Santiago, C; Pérez, M; Lucia, A
• Is Part Of: British journal of sports medicine. Volume 40:Issue 1(2006)
• Page Start: e1
• Page End: e1
• Publication Date: 2005-12-21
• Subjects: ACTN3 gene -- ageing -- muscle -- functional capacity -- strength; Sports medicine -- Periodicals; 617.1027
• DOI: 10.1136/bjsm.2005.019539
• Languages: English
• ISSNs: 0306-3674

Abstract

Abstract : The sarcomeric protein α actinin 3 is localised to the Z line of fast fibres, which are responsible for generating forceful muscle contractions at high velocity. However, a substantial proportion of healthy humans are totally deficient in this protein as they are homozygous for a premature stop codon polymorphism (R577X) in the ACTN3 gene. The purpose of this preliminary study was to assess if the presence or absence of α actinin 3 influences the deleterious effects of ageing on muscle output and functional capacity.